Endocrine Abstracts

Introduction: A successfull diabetes management is not only restricted to medical therapy but also includes a difficult and new life style adoptation. Errors frequently observed in patients such as not complying with their diet program, wrong way of doing insulin injections and insufficient insulin doses, hinder the adequate metabolic control of the disease. Also, physco-social status and different education levels complicate the effectiveness of the first training of the pati...

Introduction: Lithium carbonate therapy has continued to be a mainstay treatment for bipolar disease and schizoaffective disorders. Hypercalcemia and hyperparathyroidism (HPT) is an underappreciated, but relatively common occurence, with a prevalence ranging from 6.3 to 50% in patients requiring long-term lithium therapy. It is stil unclear whether lithium initiates HPT or promotes an underlying subclinical state. Lithium antagonizes the calcium-sensing receptor (CASR) resulti...

Objective: It is not currently well known whether pheochromocytomas can be ruled out based on low intensity on T2-weighted sequences and signal loss on out-off phase magnetic resonance imaging (MRI) sequences. Hence, in this study we aimed to investigate whether biochemical screening for pheochromocytoma in patients with adrenal incidentalomas (AI) showing MRI features not suggesting pheochromocytoma would prove beneficial.Methods: We performed MRI for 3...

Introduction and aim: Osteopetrosis is a rare genetic disorder of reduced osteoclastic bone resorption. Defective bone remodelling induces skeletal sclerosis and abnormally dense but brittle bones. We present here a case of autosomal dominant osteopetrosis type II as a cause of high bone mineral density (BMD).Case report: A 52-years-old woman with a complaint of bone pain and headache referred to our clinic for evaluation of high BMD. Her medical history...

Introduction: Primary hyperparathyroidism (PHPT) occurs a peak incidence between ages 50 and 60 and the classical bone disease of PHPT or pathological fractures due to PHPT is rarely seen today. Furthermore brown tumor detected with Tc-99m MIBI scintigraphy exists in literature infrequently.Case: A 23 years old woman presented with left arm pain admitted in Department of Orthopaedics for pathological fracture in left humerus. As a result of investigation...

Introduction: Thyrotropin secreting pituitary adenomas are rare constituting <2% of pituitary adenomas. Thirty percent of these tumors may be plurihormonal. Most common cosecreted hormone is GH and the least one is PRL. We report here a case of plurihormonal pituitary adenoma symptomatic for TSH secretion.Case report: A 35-year-old female admitted to hospital because of fatigue, heat intolerance, headache, galactorrhea and menstrual irregularity. Her...

Thyroidectomy is the definitive treatment for toxic multinodular goiter (TXMNG). Surgery should be performed when the patient is euthyroid which decreases perioperative cardiac risks. Plasmapheresis is a procedure that removes the thyroid hormones from the circulation. It is an alternative method in case of resistance or contraindications to anti thyroid drugs. Role of plasmapheresis in the treatment of TXMNG is not fully determined in the literature. We report a case with TXM...

Introduction: Sertoli–Leydig cell tumours are rare tumours which account for <1% of all solid ovarian tumors. It mostly occurs in 2–4° decades of life. Rapidly progessing symptoms/signs of androgen excess suggest the presence of and androgen secreting tumor.Case: Two postmenopausal patients (50 and 57 year-old) were referred to our Endocrinology Clinic for evaluation of worsening hirsutism. Both of patients had manifestations of hypera...

Background: Obesity and diabetes mellitus (DM) are the features of Cushing’s disease (CD). Studies indicated different frequencies of CD among obese, type 2 DM patients. The frequency of CD among obese, type 2 DM have’nt been studied in Turkey. Therefore, we aimed to assess the frequency of CD among obese (BMI>30 kg/m2) type 2 DM patients that had not classical morphological findings of CD.Patients and methods: Two hundred consec...

Background: Acromegaly is a multi-systemic dysfiguring disease caused by pituitary GH secreting tumour. Pituitary surgery, medical treatment with somatostatin analogues and radiotherapy have been cornerstone in the management of acromegaly. However, all these treatment modalities do not provide sufficient disease control especially in patients with macroadenomas.Objective: To evaluate the follow-up outcomes and remission rates of acromegaly patients....